DR. ANDREAS BEYER VISITING LECTURE

​Dr. Andreas Beyer is visiting on June 12th at 11:00 AM in EXP 610A. If you would like to meet with please RSVP to this invite. Please RSVP if you plan to attend so we can plan accordingly.

​Title: Proteotyping cells for systems-level understanding

​Abstract: To fully grasp the complexity of cellular systems we need to move beyond simple protein abundance measurements and instead map cellular proteotypes — the ensemble of proteins, their states and interactions. We have quantified the transcriptomes, proteomes and phospho-proteomes of a collection of genetically different yeast strains and devised multi-omics data integration to understand the transmission of signals across omics-layers. Our work revealed that genetic variants affecting protein phosphorylation were often distinct from those affecting protein abundance. Protein phosphorylation was more strongly correlated with cell physiological traits, underscoring the need to map protein states in addition to protein abundance. Further, our analysis showed that the spreading of genetic effects in molecular networks was largely driven by the need to maintain a homeostatic balance between distinct cellular processes. To also map protein structural changes at a systems scale, we developed computational methods for the analysis of Limited-Proteolyses Mass-Spectrometry (LiP-MS) data. Our framework deconvolves protein abundance, protein accessibility and protein sequence changes from LiP-MS data, which lead to the development of protein-structural biomarkers for Parkinson's Disease.

​His research focuses on the molecular and systems biology of aging, including how transcriptional speed, RNA quality, and protein regulation change over time, with implications for neurodegeneration, cancer, and chronic kidney disease. Learn more about his work.