HackTalk: Alex Kleinman - LLM Bio-Uplift and Agentic Biosecurity Benchmarks
HackTalk: Alex Kleinman (Active Site)
LLM Bio-Uplift and Agentic Biosecurity Benchmarks
Pre-hackathon talk. Free and open. Recording available after.
Alex Kleinman is Co-founder and Director of Operations at Active Site (formerly Panoplia Labs), a research nonprofit measuring AI's impact on biosecurity risks. He co-led the wet-lab RCT on whether LLMs provide biological uplift to novices, contributed to ABC-Bench (an agentic biosecurity benchmark presented at NeurIPS 2025), and co-authored a study on antibiotic and vaccine countermeasures against mirror bacteria. Before Active Site, he was on the science team at Alvea, working on broad-spectrum vaccines.
He'll share what the empirical evidence on AI bio-uplift is actually showing so far and where agentic benchmarks fit in the wider AIxBio evaluation picture.
Format: 10 min talk + 10-20 min Q&A and discussion.
Part of the AIxBio Hackathon pre-event programming.