

Why you should "start with the science," with Mark Johnson (Zite, Descartes Labs, Gallup)
Most product playbooks start with “the customer problem.”
But some of the most important companies of the last 20 years started somewhere else: a scientific breakthrough.
In this conversation, Mark (product leader and 3x CEO) shares what it actually takes to commercialize science — based on a career building companies spun out of research labs (including startups originating from Stanford, Xerox PARC, university research, and Los Alamos National Laboratory).
We’ll explore:
Why “start with the science” can unlock entirely new product surfaces
The core risk: investing in a science thesis without a market thesis
How to narrow from “this tech can do a million things” to a real product:
capabilities → constraints → markets → use case → revenueThe consulting-vs-product trap
What modern AI commercialization teaches us about the same pattern today